Category Archives: pipeline biotech

Pipeline biotech

All rights reserved. When it comes to biotech stocks, a company is only as good as its pipeline. No drug can remain profitable forever.

Biotech Pipeline Planning & Strategic Marketing - San Diego

Patents expire and much cheaper competition arises. New, more effective drugs are developed to treat the same diseases better or with fewer side effects. So for a biotech stock to remain strong in the long term, drug companies need to consistently put out new, cutting-edge therapies. As important if not more important is how novel these new drugs are. If a new drug is developed to treat a disease that is already well-managed by a series of pre-existing therapies, then many will not opt for a new, often more expensive, treatment.

So here are five biotech stocks with promising pipelines. All of these companies have drugs that should be receiving Food and Drug Administration approval soon and that appear to fill a strong need.

Amgen Inc. Of the whopping eleven drugs currently in phase 3 trials, two are close to FDA approval. Aimovig is a treatment for the prevention of episodic migraines. Amgen has submitted Aimovig to the FDA for review. Meaning that the FDA aims to complete its approval by this date unless more information is needed from Amgen. Aimovig is a fully-human monoclonal antibody. Monocolonal antibodies are laboratory created cells designed to attach to specific receptors within the body.

Aimovig was specifically designed to block the CGRP receptor — which plays a critical role in migraine activation. Other preventative migraine medications are often stopped due to lack of efficacy or intolerable side effects. Topamax, the top migraine prevention drug currently available has a long list of disruptive side effects. Aimovig, meanwhile, has shown much fewer side effects. However, Amgen is seeking approval for Blincyto to treat a different type of cancer. Minimal residual disease-positive B-cell precursor acute lymphoblastic leukemia or MRD positive ALL does not currently have any treatments specified to treat it specifically.

Seattle Genetics, Inc. ADC, or antibody-drug conjugates, technology combines the specificity of monoclonal antibodies with the power of cancer-cell-killing cytotoxic agents. Monoclonal antibodies cut down on the widespread cell destruction that happens with many chemotherapies by targeting markers found only on cancer cells.

Once the monoclonal antibodies bind to the cancer cells, the cytotoxic agents disrupt cell processes in order to kill the cells. SEA, or sugar-engineered antibody, technology increases the potency of monoclonal antibodies. Seattle Genetics combines these technologies in order to develop specified treatments. Spectrum Pharmaceuticals, Inc. Rolontis has met targets for stage 3 trials and a final phase 3 study is underway. The company plans to file a biologics license application BLA in the fourth quarter of A BLA is a request for permission to introduce a biologic product into interstate commerce.Our current pipeline consists of new molecular entities with relevant mechanism of actions in skin diseases, targeting significant market opportunities in the global dermatology market.

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It is mandatory to procure user consent prior to running these cookies on your website. OVERVIEW Our current pipeline consists of new molecular entities with relevant mechanism of actions in skin diseases, targeting significant market opportunities in the global dermatology market. Sofpironium Bromide. Retrometabolically designed topical anticholinergic for primary axillary hyperhidrosis.

pipeline biotech

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Necessary Always Enabled. Non-necessary Non-necessary.All rights Reserved. Current Events Omeprazole As An Additive For Coronavirus Therapy 13 April, One of the notable things about the current pandemic is the way that all our modern biology and analytical techniques are on display.

Molecular biology, structural biology, bioinformatics, technologies like cryo-EM structure determination, fast sequencing, protein interaction screening and more — this is a real-time look at how basic biomedic… Read More. We have new data on hydroxychloroquine therapy to discuss. The numbers will not clear anything up. Didier Raoult. It includes the statement… Read More. Time for a word about screening for new coronavirus drugs. Things have gone on long enough for quite a few groups to produce supplies of the various viral proteins and set up small-molecule screens against them.

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I wrote here the other day on the recent recommendation that people taking either ACE angiotensin-converting enzyme inhibitors or ARBs angiotensin receptor blockers should not alter their treatment regimens because of the coronavirus outbreak. My previous reviews of the clinical data in this area are here. First up is this study from France.

Mounting an antibody response is crucial for anyone to overcome a challenge from an infectious pathogen, and the immunity that can result is crucial for entire communities and populations. Determining who has such immunity is furthermore going to be crucial for us as we come out from under the current pandemic.

If… Read More. One of the questions that shows up often in the comments to the various Covid posts here especially this one and very often in my own emails is whether people who are taking hypertension medications should alter their drug therapy based on the coronavirus epidemic. Categories "Me Too" Drugs 32 Academia vs.Research and development is the lifeblood of biotech companies.

pipeline biotech

The potential for new drugs also serves as a primary factor driving biotech stocks higher and higher. These three biotechs boast some of the most promising pipelines around. Here's what sets Celgene, Ionis, and Ligand apart from the pack.

Celgene's pipeline includes 15 late-stage programs plus two awaiting regulatory approval. Several of those studies are evaluating drugs already on the market in treating additional indications.

However, Celgene also claims some new candidates with huge potential. The big biotech has partnered with Acceleron Pharma on luspatercept. Celgene has even greater prospects with its autoimmune disease candidates. GED is in a late-stage clinical study for treating Crohn's disease and a mid-stage study for treating ulcerative colitis. Ozanimod is being evaluated in two late-stage clinical studies: one for treating relapsing multiple sclerosis and the other for treating ulcerative colitis.

The experimental drug is also in a mid-stage study targeting treatment of Crohn's disease. Ionis is a lot smaller than Celgene, so it makes sense that the company wouldn't have as many pipeline candidates.

But what the biotech does have could be game-changers.

Development Pipeline

Three of Ionis' candidates are in late-stage clinical trials. Both are rare genetic disorders. FCS, in particular, has no approved treatment in the U. A late-stage study of the experimental drug is expected to wrap up in the first half of this year. The candidate is in a late-stage study targeting treatment of multidrug-resistant gram-negative bacterial infections.

In addition, Ionis' pipeline includes 13 mid-stage programs. These programs target diverse indications, from cancer and cardiovascular diseases to rare diseases.

pipeline biotech

Thanks to its unique business model, though, the company boasts one of the bigger pipelines around. Ligand has seven late-stage candidates and 20 mid-stage candidates.

How does such a small biotech build such a large pipeline? Ligand markets technology that helps other biopharmaceutical companies develop drugs more effectively. Ligand's partners read like a "who's who list" of the biopharmaceutical world. Over 90 companies either partner with Ligand or license its technologies. The experimental drug is in two late-stage studies conducted by Sage Therapeuticsone targeting treatment of super-refractory status epilepticus and another targeting treatment of postpartum depression.

Focused on rapidly developing cell therapies

Both Ionis and Ligand claim impressive pipelines. However, both must split profits with larger partners. Although Celgene has several partnerships also and won't reap all of the rewards if its pipeline candidates succeed, the big biotech is in a better position to make more money from its pipeline than either Ionis or Ligand.

Feb 15, at PM. Author Bio Keith began writing for the Fool in and focuses primarily on healthcare investing topics. His background includes serving in management and consulting for the healthcare technology, health insurance, medical device, and pharmacy benefits management industries.

Follow keithspeights. Image source: Getty Images. Stock Advisor launched in February of Join Stock Advisor. Related Articles.The word pipeline in biotech companies generally refers to the stages of clinical trials. The pipeline overall is the group of unique products or processes reported or in development by a company. Drugs that have entered into clinical trials and are pending approval by the U.

Likewise, a product in the pipeline is one that we can anticipate hearing more about and possibly using in the future. A clinical study involves research using human volunteers also called participantswhich is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials also called interventional studies and observational studies.

Clinical studies can take place in many locations, including hospitals, universities, doctors' offices, and community clinics. The location depends on who is conducting the study. Clinical trials are conducted in a series of steps, called phases, and each phase is designed to answer a separate research question. You can search clinical trials on the government site ClinicalTrials. Goals such as building the pipeline, or reaching different stages of clinical trial, are among the milestones set by pharmaceutical companies and venture capitalists.

Genentechfor example, lists numerous drugs in its pipeline from various areas of medicine—oncology to immunology. A biotech company's pipeline of up-and-coming products is a critical factor in evaluating its investment potential. Therefore, market analyst's reports on company pipelines are an important investment tool. However, the value of each individual pipeline drug depends upon its progress through clinical trials and, ultimately, approval.

When evaluating a company pipeline, each drug is assigned a weighted value which increases as it progresses through these trials. Biotech Industry Biotech Glossary. By Full Bio Follow Linkedin. Follow Twitter. She has worked as an environmental risk consultant, toxicologist and research scientist.

Read The Balance's editorial policies. Continue Reading.EXD is a live attenuated vaccine candidate being researched and developed to prevent and treat the Herpes Simplex Virus.

pipeline biotech

EXD is going to be tested as a prophylactic and therapeutic vaccine candidate in the guinea pig model. We hope to have published preclinical data by year end Herpes Vaccine Excell Biotech is setting out to clinically test a Herpes vaccine which may be also a possible therapeutic intervention in humans. For 30 years, vaccines against Herpes have failed. Research groups have tried subunit vaccines repeatedly and failed. New data indicates that glycoprotein D acts as a decoy, so the immune system is not able to form an effective antibody response to other antigens.

Without glycoprotein D, Herpes is visible to the immune system and is also unable to spread between cells. Most people think of it just as an annoyance but there are lots of diseases associated with Herpes. A big question is whether this therapy can confer cross-protection against Eppstein-Barr virus and CMV, as a paper suggests that HSV antibodies can be cross-reactive.

Currently we have produced HSV particles and used transmission electron microscopy to confirm that they are intact and devoid of other contaminating viruses. The absence of contaminating viruses was further proven by PCR testing. Previous studies have shown that in the production process, self rescuant viruses can arise and become wild-type.

While research groups have used two different safety switches individually, we combine at least 4 different layers that guarantee that no infectious virus can arise. Toggle navigation.All rights reserved. As market conditions turn positive again and the major indices close at a new high, value investors should turn to the healthcare sector.

Biotechnology stocks are far from their week highs. And even though worries over pressured drug prices are dissipating, biotech stocks did not fully rebound. Investors should look for two key aspects with biotech stocks. They should pick companies that already have products on the market and whose profits more than cover research spending. They should also demand companies with plenty in the pipeline.

With those requirements, companies are unlikely to seek an additional cash boost through the sale of shares. That gives investors the biggest upside potential with the least amount of risk. On Oct.

Prevailing Over HDV

The company reviewed the clinical data again and decided the drug does work. Its terminated Phase 3 Emerge study met the primary endpoint. It continued to progress its pipeline with Vemerity and the addition of two new clinical programs.

Its pipeline for multiple sclerosis drugs continued growing in the third quarter. Positive results for one of its studies on multiple sclerosis suggest strong product sales in the future. It will further build depth across its ASO pipeline by focusing on genetically validated targets. Although its blockbuster drug Humira faced generic competition, it still grew sales by 9. It reported strong volume growth across all three segments: rheumatology, dermatology and gastroenterology.

AbbVie advanced its pipeline with recent product Rinvoq. In atopic dermatitis, Rinvoq results will be posted in the first half of In hematologic oncology, Imbruvica and Venclexta are advancing its product pipeline. Expect favorable study updates to give ABBV stock another lift. The company managed its mature product line and will have more than enough cash flow to grow its dividend and service the debt incurred through the Allergan buyout.


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